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6057 |
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Date: September 21, 2015 at 21:50:26
From: BJ, [DNS_Address]
Subject: Alpha Lipoic Acid for Burning Mouth Syndrome |
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No health board. Any complaints let me know
"Summary by:
Dr. Tori Hudson, N.D.
Author:
Palacios-Sanchez B, Moreno-Lopez L, Cerero-Lapiedra R, et al.
Reference:
Alpha lipoic acid efficacy in burning mouth syndrome. A controlled clinical trial. Med Oral Patol Oral Cir Bucal 2015;1;20(4): e435-440.
Design:
This double-blind placebo-controlled study was conducted in Madrid, Spain in which patients were randomly allocated to either placebo or alpha lipoic acid (ALA). All participants were assessed for salivary flow rates, complete blood count, ferritin, vitamin B12 and folic acid. Treatment was 600 mg/day of ALA at 200 mg every 8 hours for 2 months, or placebo every 8 hours for 2 months. Patients were assessed every 15 days for changes in symptomatology and for side effects. Final results were obtained after two months.
Participants:
Sixty patients (55 women and 5 men) over the age of 18, with a mean of 62 years, with burning mouth syndrome for more than 4 months and no clinical objective signs. The duration of symptoms in patients was between 4 months and 20 years. The average intensity was 6.6, with a range of 2.5 to 10. Burning symptoms were the most common symptom in 63.3% of the patients and stinging in 20%. The rest reported itching or other symptoms with the tongue being the most affected site. In addition to burning, 10 patients had dysgeusia, 13 had xerostomia and 24 patients reported both symptoms that occurred concurrently. Stimulated and unstimulated salivary flow was reduced in 25 patients. About one third of the participants associated the onset of their burning mouth syndrome symptoms with a dental treatment.
Exclusion criteria included patients who had local oral lesions or alterations, unmanaged systemic diseases, patients on cisplatin, cyclophosphamide, gentamicin or amikacin and patients already undergoing any type of treatment for their burning mouth syndrome.
Primary outcome:
The primary outcome was measured using a visual analog scale as mild improvement (50-75%), great improvement (> 75%) or complete amelioration of symptoms.
Key findings:
Results were divided into three categories: slight improvement, decided improvement/resolution, and no change or worse. Eight of the 20 patients (27.5%) who received placebo showed some level of improvement, 5 worsened (17.2%) and 16 had no change (55.2%). Sixteen of the 5 patients who received ALA (64%) improved, 9 (36%) had no changed, and none worsened. One month after the end of the treatment, 4 of the 8 patients who had improved in the placebo group had a relapse of burning. About one third (5 of 16 patients) with signs of improvement taking ALA worsened one month after treatment was discontinued.
Practice Implications:
Burning mouth syndrome occurs more frequently in middle-aged and elderly individuals and is more prominent in women, about a 7:1 ratio. The precise cause of burning mouth syndrome is unknown although multiple local and systemic factors exist. Local factors associated with burning mouth syndrome include: hyposalivation and/or xerostomia, parafunctional habits, contact allergies, poor fitting oral devices, Candida albicans oral infection, smoking, alcohol, caffeine and hot or spicy foods. Systemic factors associated with burning mouth syndrome include menopause, nutritional deficiencies (B vitamins, iron, and folic acid), type II diabetes, hypothyroid and select medications (i.e., antihypertensive drugs).
Previously published research on ALA has demonstrated efficacy and is probably one of the most effective treatments for burning mouth syndrome.1 The most common dose studied is 600 mg/day, as in the current study. ALA at 600 mg/day in divided doses should be at the top of every clinician’s list for treating burning mouth syndrome.
1J Oral Pathol Med. 2013 Oct;42(9):649-55.
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Responses:
[6065] [6066] [6067] [6063] [6073] [6076] [6058] |
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6065 |
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Date: September 23, 2015 at 09:50:37
From: mr bopp, [DNS_Address]
Subject: Re: Alpha Lipoic Acid for Burning Mouth Syndrome |
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health board is reopened...we'll see how it goes...
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Responses:
[6066] [6067] |
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6066 |
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Date: September 23, 2015 at 17:39:44
From: BJ, [DNS_Address]
Subject: Re: Alpha Lipoic Acid for Burning Mouth Syndrome |
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not well I see.
Did you block the IP?
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Responses:
[6067] |
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6067 |
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Date: September 23, 2015 at 18:12:42
From: mr bopp, [DNS_Address]
Subject: Re: Alpha Lipoic Acid for Burning Mouth Syndrome |
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they keep changing it..i'll play with it for a while...if i can't stop em i'll close it again...
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Responses:
None |
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6063 |
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Date: September 22, 2015 at 23:09:43
From: Linn in Pahrump, [DNS_Address]
Subject: Magnesium supplement fixed mine.(NT) |
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Responses:
[6073] [6076] |
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6073 |
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Date: September 29, 2015 at 00:24:25
From: Terra11, [DNS_Address]
Subject: Magnesium supplement Linn I just have to ask Is Art back in parump?(NT) |
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Responses:
[6076] |
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6076 |
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Date: September 29, 2015 at 22:19:35
From: Linn in Pahrump, [DNS_Address]
Subject: Re: Magnesium supplement Linn I just have to ask Is Art back in... |
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Heya Terra, as far as I know he is. I can't hear his broadcast on my computer, tho. I have a new computer and it's on Linux and I can't figure out what I'm doing wrong. I can hear other broadcasts just fine. Total bummer.
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Responses:
None |
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6058 |
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Date: September 21, 2015 at 22:04:56
From: Jody/Concord,CA, [DNS_Address]
Subject: Re: Alpha Lipoic Acid for Burning Mouth Syndrome |
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Thanks BJ--good stuff! Blessings, Jody
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Responses:
None |
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