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14783 |
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Date: April 05, 2024 at 08:33:12
From: The Hierophant, [DNS_Address]
Subject: Sometimes it can be generations ago |
URL: https://www.msn.com/en-us/health/other/toxic-chemicals-your-grandparents-were-exposed-to-are-likely-affecting-your-health-new-research-claims-here-s-how-it-works/ar-BB1hF3iM?ocid=hpmsn&cvid=168afd30a82c4e4eb40ffb5f97884e71&ei=15 |
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that are making us unwell today and could explain the
increase in cancers...
"Toxic chemicals your grandparents were exposed to are
likely affecting your health, new research claims.
Here’s how it works
If you find yourself battling chronic disease, your DNA
and the environment may not be to blame as much as the
chemical exposure of your ancestors.
That’s according to an article published this month in
the journal Environmental Epigenetics, by a team at the
University of Washington.
Researchers exposed three successive generations of
rats each to a single toxicant, in a bid to mimic the
exposure of humans to different eras of chemicals. The
first generation was exposed to the fungicide
vinclozolin, a pesticide that kills various diseases on
raspberries, lettuce, kiwi, grapes, and turf. A known
endocrine disruptor, vinclozolin can affect sex organ
development and fertility, as well as delay puberty.
The second generation of rats was exposed to a jet fuel
hydrocarbon mixture. And gestating females from the
third generation were exposed to the pesticide
dichlorodiphenyltrichloroethane, also known as DDT.
Marine biologist Rachel Carson famously warned of the
dangers of the pesticide, which was manufactured en
masse during World War II, in her 1962 book Silent
Spring.
Three additional, non-exposed generations were bred
before the rats were examined. Washington state
researchers looked for changes to their epigenome,
which consists of chemicals that modify the genome,
telling it “what to do, where to do it, and when to do
it”—almost like computer software. The epigenome can be
influenced, or “reprogrammed,” by environmental factors
like stress, diet, drugs, pollution, and toxicants.
Resulting changes can be passed down from cell to cell
as they divide, within an individual—and from
generation to generation, among family members.
The scientists observed “compounded disease impacts”
over time, with toxicant exposure shifting each
generation’s epigenetics “dramatically.” The incidence
of obesity, kidney disease, and prostate disease
increased in each subsequent generation after the first
toxicant exposure. By the time the rats were bred out
to three unexposed generations, their risk of such
conditions had risen by as much as 70%.
Previous research has only examined the impacts of
single-generation exposures to toxicants, Michael
Skinner, a professor of biology at WSU and the study’s
corresponding author, tells Fortune.
“We found that if multiple generations get different
exposures, eventually there’s an amplification or
compounded effect on some diseases,” he says.
Both the U.S. and Europe have obesity rates around 50%
and are three generations down the line from initial
exposure to DDT in the 1950s, he points out, suggesting
that changes in the epigenome caused by generational
exposure to toxic chemicals had created a population
that’s more susceptible to disease, including obesity.
A person today who eats a high fat, high sugar diet may
very well develop obesity. But their ancestors who
weren’t exposed to such toxicants may not have, even if
they ate the same unhealthy diet, he asserts.
“What this tells you is that what your grandparents
were exposed to is going to give you and your children
and grandchildren conditions and will continue to
subsequent generations,” he adds. “It’s not your direct
exposure, so much.”
The genome as a minor player
Such transmission of diseases through generations is
known as epigenetic transgenerational inheritance, a
“non-genetic form of inheritance that we now realize
exists,” Skinner says.
The impact of various environmental factors—like
climate, nutrition, and toxicants—on the epigenome has
been shown to extend tens of hundreds of generations in
fruit flies and hundreds of generations in plants.
“With mammals, we’ve only been capable of going out 10
or 20 generations,” he says. “But we see transmission
as well.”
While a person’s DNA is an important factor in the
development of disease, it’s not as crucial as the
epigenome, Skinner says. Case in point: Genetic
mutations found in the BRCA1 and BRCA2 genes, made
famous by Angelina Jolie’s 2013 New York Times op-ed,
are found in only 1% to 7% of breast cancer patients
who don’t have a family history of the disease.
“It’s not really what is regulating biology that much,”
Skinner says of such genetic errors. Of the numerous
DNA mutations each person has, only 1% might contribute
to disease.
“It’s changes in epigenetics that can give you a
disease [presentation] or make you taller or shorter or
obese or not obese,” he says.
Case in point again: breast cancer.
Breast cancer is caused by far more than a single gene,
he says. “If you take the BRAC2 gene, which is one of
the first genes that has a really good association with
breast cancer—and you look at 100 people with breast
cancer, only one of those 100 people may have a
mutation in BRAC2.”
“The idea that a single or even a small number of genes
are controlling biology is not accurate,” he adds. “It
takes hundreds, if not thousands, of genes” to result
in any one medical condition—and all contributing genes
must be “turned on” by the epigenome.
The study is a wake-up call as to just how much
environmental exposures influence health, Skinner says—
if not our generation's health, undoubtedly the next’s,
and perhaps in perpetuity.
“Now we realize that what we’re doing to ourselves in
terms of exposure is not so much impacting us, though
it can,” he adds. “But it’s having dramatic effects on
subsequent generations.”
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Responses:
[14784] [14785] [14790] [14794] [14802] [14805] [14806] [14789] [14803] |
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14784 |
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Date: April 05, 2024 at 15:22:14
From: EQF, [DNS_Address]
Subject: DNA Wrapping - Apr. 5, 2024 |
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Posted by EQF on April 5, 2024
Hi Hierophan,
Are you one of those powerful space aliens?
Humor intended. I had to do some reading to determine what name stands for.
I have several degrees in the physical sciences. I am not an expert in biology and it required some reading to determine what the differences are between genome and epigenome.
You might comment on if I got this right or not.
Genome in humans generally refers to information in our DNA. I don't know if RNA information falls into the genome category.
Our DNA functions are controlled not only by the chemical composition of the DNA but also by how the extremely complex DNA molecule is wrapped up, or how it folds itself within the cell. It can behave differently from one person to another depending on how it is folded in each individual.
Epigenome in humans generally refers to groups of chemicals or molecules that the DNA will wrap itself around so that it takes a certain shape inside the cell.
Those epigenome chemicals are technically not a part of the actual DNA molecule. But once the DNA wraps around them they can be passed along during cell division and from generation to generation of parents and children.
If two identical twins are raised in different environments and one of them is exposed to certain types of epigenome chemicals or molecules then he or she will to some extent be able to pass the epigenome material along to his or her children.
But, his or her identical twin will not pass along that material, having never been exposed to it. The two family lines will then be different from one another even though they got started with identical twins.
That is interesting information. I am glad that was not covered when I was in biology class many years ago or I would likely have been even more confused than I am today.
It is my understanding that Mr. Bopp has a degree in physics. I predict that he will be even more in the dark about all of this than I am (humor intended).
These are personal opinions.
Regards to all,
EQF
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[14785] [14790] [14794] [14802] [14805] [14806] [14789] [14803] |
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14785 |
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Date: April 05, 2024 at 18:05:05
From: The Hierophant, [DNS_Address]
Subject: Re: DNA Wrapping - Apr. 5, 2024 |
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First, I guess I need to welcome you to the boards -
other than March of this year, I can't find any other
posting by you, so am thinking you might either be a
lurker who hasn't posted much or are a newcomer
Your description of the twins is pretty spot on -
however, it also would need to take into consideration
that because the embryos develop independently after
the zygotes split, and errors in the epigenetic
process, such as modification of the wrong gene or
failure to add a chemical group to a particular gene or
histone, can lead to abnormal gene activity or
inactivity, identical twins can have different health
conditions, physical differences, and other small
changes that make each member of the pair different
from the other. So given the subject matter - one twin
might inherit some fragments of DNA from a great great
grandmother while the other twin might have some from a
great great great grandfather, because, as the article
states “The epigenome can be influenced, or
“reprogrammed,” by environmental factors like stress,
diet, drugs, pollution, and toxicants. Resulting
changes can be passed down from cell to cell
as they divide, within an individual—and from
generation to generation, among family members.
if multiple generations get different exposures,
eventually there’s an amplification or compounded
effect on some diseases.”
Idk - did I address what you were seeking?
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Responses:
[14790] [14794] [14802] [14805] [14806] [14789] [14803] |
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14790 |
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Date: April 06, 2024 at 20:57:02
From: EQF, [DNS_Address]
Subject: Generally - Yes - Apr. 6, 2024 |
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Posted by EQF on April 6, 2024
Hi Hierophant,
It appears that the answer to your question is "Yes." You did generally answer my main question.
I was interested in learning if my interpretation of the difference between genome and epigenome was correct. I already knew about all of the other information you posted regarding identical twins etc. But I had never before seen any discussions of what causes the DNA molecule to fold the way that it does in a given cell.
However, I am still interested in learning if RNA information is included in the "genome" category. I am guessing from past reading that many RNA molecules get duplicated when a cell splits and probably when a baby first starts to develop.
FORUM PARTICIPATION
I have been posting notes to various forums probably longer than anyone has been posting notes to these Boppin forum boards.
Another person and I created a forum decades ago through an organization called "QuakeNet.org." It was likely one of the first Internet forums ever, predating this Boppin forum. I don't know if that other person is even still alive after all these years.
Almost all of my past posts have been related to earthquake forecasting. If you visit the "Rock and Roll" forum on this Web site you will see my posts going back a long ways in time. Not too long ago I started posting to other forums including the Science forum and this one.
Occasionally I have had to change the Pen Name under which I post notes to these forums to keep some problems from developing or getting worse.
The Internet is not the safest environment in which to do business. There are some nasty people and organizations out there. People should learn how to protect themselves from those people and organizations. Using a Pen Name with posted notes is one way of doing that.
MY OWN WEB SITE
If you want to see my Earthquake Forecasting Web site you can go to any major search engine and type in:
earthquake research index.html Data.html
My Web site should be at or near the top of the returned list.
There are numerous reports there about Earthquake Forecasting and one report related to my work associated with getting Renewable Energy resources developed.
These are personal opinions.
Regards to all,
EQF
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Responses:
[14794] [14802] [14805] [14806] |
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Date: April 07, 2024 at 14:52:16
From: The Hierophant, [DNS_Address]
Subject: were you on |
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Job's eq boards because I was there since it's inception
and interacted with him since about 1996.
Re the scientific part of your question - will address it
a little later - between celebrating a 'legally' 34th
wedding anniversary today, coupled with the 'big event'
tomorrow and the plethora of readings I am doing for
clients....will do my best to get to it soon.
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Date: April 11, 2024 at 15:54:43
From: EQF, [DNS_Address]
Subject: Forecasting Forum - Apr. 11, 2024 |
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Posted by EQF on April 11, 2024
I knew that Job had a from for a long time. I can't remember when I first learned about it.
I don't remember exactly when the QuakeNet Earthquake Forum got started. I will likely have to access some of my very old E-mail and data storage drives to determine when it got up and running.
QuakeNet eventually evolved into two Earthwaves forums. One was a Yahoo forum. The other was privately run by someone named Canie who kept it going for a long, long time.
There were LOTS of very heated earthquake forecasting discussions on that forum. Some involved experienced scientists.
Quite a few other forum posters were "Earthquake Sensitive." They could somehow sense energy waves that were associated with approaching powerful earthquakes and probably certain types of solar storms.
Very strong Earthquake Sensitivity can be a serious medical problem. In extreme cases it can reportedly cause small blood vessels near the skin surface to rupture. A number of people with whom I have talked over the years had to be repeatedly hospitalized when earthquakes were approaching.
People in the medical community should be aware of this particular medical problem. There are a few. But most medical people seem to have never heard about it. Often when they talk with people who are Earthquake Sensitive they believe that they are simply imaging things.
I do expect that a good fraction of the people who posted notes to the QuakeNet board have gone on to their eternal rewards. I know of at least two who died years ago.
These are personal opinions.
Regards to all,
EQF
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Date: April 13, 2024 at 15:43:17
From: Nabcy Hugo, [DNS_Address]
Subject: Re: Forecasting Forum - Apr. 11, 2024 |
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Many sensitives end up with a diagnosis of biplar
disorder. Suicide, strokes, heart attacks, and various
other vascular problems can be a problem for
sensitives...this can lead to death. Seismic activity in
Chile can lead some sensitives to become extremely
irritable. Being nearthquake/seismic sensitive can be
very challenging.
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[14806] |
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Date: April 18, 2024 at 11:19:43
From: EQF, [DNS_Address]
Subject: Strong Earthquake Sensitivity - Apr. 18, 2024 |
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Posted by EQF on April 18, 2024
Hi Nancy,
Are you the Nancy who posted notes to the QuakeNet and Earthwaves forums in the past?
If so then you know who I am. For security reasons I am just using a different "Pen Name" with my present posts to the Boppin forum.
EARTHQUAKE SENSITIVITY
Over the decades I have had many, many discussions with people who are strongly Earthquake Sensitive.
It might surprise you to know that quite a few medical personnel in different countries have known for a long time that something is going on with this. However, that does not seem to be the case for medical personnel here in the U.S.
I myself actually formally published a technical paper on Human Earthquake Sensitivity many, many years ago. I also own the copyright for the original paper.
"Bipolar Disorder" covers a lot of ground. Generally, I believe that it is regarded as being related to a person's DNA, his or her brain structure, and his or her blood chemistry.
Earthquake Sensitivity appears to be more associated with interactions between electromagnetic energy field effects and the human brain and body. That can be demonstrated in the laboratory.
Symptoms can be similar to Bipolar Disorder. That might be the main reason that inaccurate diagnoses are being made. Medical personnel incorrectly conclude that Earthquake Sensitivity symptoms are the classic type of Bipolar Disorder.
Earthquake Sensitivity and classic Bipolar Disorder are each bad enough on their own. However, the most DANGEROUS condition probably involves having a person who has a classic Bipolar Disorder and who is also Earthquake Sensitive move to or be born near an area where there is an active earthquake fault zone.
If that person has a Bipolar Disorder attack at the same time that an earthquake is approaching, the two symptoms added together can likely often be fatal.
In the past, what I have recommended to people who are strongly Earthquake Sensitive is that they try to live in a location where there are no active fault zones. However, I have been told on occasion that this doesn't work all the time.
What I would recommend is that people who are strongly Earthquake Sensitive make an effort to try to take a vacation for several months and stay in an area where there are no active fault zones and see if that helps. If it does, they can try to make the move permanent rather than have to deal with severe symptoms.
Some people have done that with success.
However, many Earthquake Sensitive people who live on the U.S. West Coast like the area where they live so much that they are willing to put up with the occasional headaches and nausea etc.
Discussions I have had with people indicate to me that if a person is strongly Earthquake Sensitive and he or she thinks about earthquakes all the time, the symptoms can get worse. That has to do with how the human brain works. It is probably better to think about floods.
Additionally, Earthquake Sensitivity appears to often be contagious. If one person in a family is strongly Earthquake Sensitive then other people in the family such as a new spouse may start to develop symptoms. This likely has to do with the way the human brain works.
Amusingly, that appears to also be the case at times for pet animals. They can develop similar symptoms though it might be that they are just responding to body language etc. by their owners when an earthquake is approaching.
These are personal opinions.
Regards to all,
EQF
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Date: April 06, 2024 at 15:53:58
From: Sue/Seattle, [DNS_Address]
Subject: Re: DNA Wrapping - Apr. 5, 2024 |
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Cool study from my Alma Mater. As far as twins go we can
also look at nature vs nurture which was a big deal when
I went to college. Im curious now what Covid will do to
our future generations. It was surprising to me DNA did
not play as big a factor as I thought it did. I need to
re-read this study a few more times
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[14803] |
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Date: April 11, 2024 at 16:03:10
From: EQF, [DNS_Address]
Subject: Covid 19 And Blood Type - Apr. 11, 2024 |
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Posted by EQF on April 11, 2024
It is my understanding that a person's blood type is partly related to his or her DNA.
So, a person might have A or B or O, positive or negative etc. depending on the DNA given to him or her by his or her parents.
Something that really surprised me is the fact that at least some people in the medical community are not aware that a person's resistance to serious Covid-19 infections does have something to do with his or her blood type.
Early news reports that were based on discussions in the medical community indicated that this was the case. Doctors were asking:
Where are all the patients with O type blood who SHOULD be here in the hospital? Apparently there weren't as many as would be expected.
People with O type blood reportedly generally have the highest resistance. I think that people with A type have the lowest resistance.
So, THAT factor involved with Covid-19 does apparently have something to do with a person's DNA.
These are personal opinions.
Regards to all,
EQF
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